Carrying Portal Scrolls is usually recommended unless a player is using the Portal skill gem. Players may also use Portal Scrolls to go in and out of town, to immediately refill flasks and heal to full while in the middle of combat. However, this strategy has limited value in a map since the number of portal trips is limited to six. Because Portal Scrolls are quite common, it is typical for players to use Portal Scrolls more slowly than the rate at which they drop.

This item cannot be used while in a master's mission area, such as Temporal incursions provided by Alva or Syndicate Laboratory (side area where Research division of Immortal Syndicate encounter happens during missions of Jun). Also portals disabled in the Abandoned Citadels, no matter if it's currently inhabited by Conquerors or empty, in other words: portals disabled during the fight with a Conqueror, after the fight, and any other time inside Abandoned Citadel found in the map.