An Io rune is a low-mid rune which can be socketed into equipment in Diablo 2 Resurrected. Io runes are somewhat rare, but their value tends closer to low runes, due to a lack of popular uses. Socketing an item with an Io rune increases the item's levle requirement to 35, unless it was already higher.


16-IoIo(Number 16)
Clvl Required 35

Weapon: +10 Vitality
Armor/Helm/Shield: +10 Vitality

The Countess's extra rune drops on nightmare or hell difficulty can include Io runes. The Hellforge on nightmare or hell difficulty has a 1 in 11 chance to drop an Io rune as part of its quest reward. The Act 1 (N) Good treasure class has a chance to drop an Io rune, as do higher Good treasure classes. In single-player, open or ladder games only, the Horadric Cube can transmute three Hel runes and one chipped diamond into one Io rune.

Io runes are used in six rune words.

  • Memory 'LumIoSolEth' staff
  • Black 'ThulIoNef' club, hammer or mace
  • Pride 'ChamSurIoLo' polearm (ladder only)
  • Delirium 'LemIstIo' helm
  • White 'DolIo' wand
  • Dream 'IoJahPul' helm or off-hand armor (ladder only)

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